Medical Microbiology and Immunology

Z. Kevin Pan, M.D., Ph.D.

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-The structural features of the innate immune receptors and the structural changes by which binding of a microbial ligand to the receptor leads to intracellular signaling cascades.

-Negative feedback regulation of inflammatory responses, including septic shock, rheumatoid arthritis, and airway inflammation.

-G protein-coupled chemoattrant receptors function and biology.

Dr. Pan received his M.D. and Ph.D. in 1991 at the Shanghai Second Medical University. After postdoctoral training in the Department of Immunology at The Scripps Research Institute (La Jolla, CA), he was appointed to the faculty of the Molecular and Experimental Medicine Department at The Scripps Research Institute. Dr. Pan joined the Department of Medical Microbiology and Immunology in 2003.

Current Grant Funding:
Human Neutrophil-Dendritic Cell Hybrids
KHK, Co., Ltd.
Role: P.I.

Prior Grant Funding:
"Bacterial, Signaling & Leukocyte Transcription Activation"
NIH, RO1 NIAID AI-43524
Role: P.I.

"LPS Signaling and Lung Innate Immunity"
NIH, RO1 NHLBI HL-69425
Role: P.I.

"LPS, Alveolar Macrophages & Asthmatic Inflammation" (Project 3)
NIH Program Project, PO1 NIAID AI-50498
Role" P.I. on Project 3

 

Recent Publications:

Franco JH, Harris RA, Ryan WG, Taylor RT, McCullumsmith RE, Chattopadhyay S, Pan ZK.    Retinoic Acid-Mediated Inhibition of Mouse Coronavirus Replication is Dependent on IRF3 and CaMKK.   MDPI Viruses. 16(1), 140; 2024. https://doi.org/10.3390/v16010140

Dolin HH, Franco JH, Chen X, Pan ZK.   Retinoic Acid-Induced Regulation of Inflammatory Pathways Is a Potential Sepsis Treatment.    Infect Immun. 2023 Mar 6:e0045722. doi: 10.1128/iai.00457-22.

Franco JH, Pan ZK.   Retinoic Acid Induced Cell Signaling as a Counter Against Disease.   Journal of Cellular Signaling. 2023; 4(4): 187-198.

Franco JH, Chattopadhyay S, Pan ZK.   How Different Pathologies Are Affected by IFIT Expression. Viruses. 2023; 15(2):342.

Franco JH, Chen X, Pan ZK.   Novel Treatments Targeting the Dysregulated Cell Signaling Pathway during Sepsis.    J Cell Signal. 2021 Dec;2(4):228-234.  

 Yao YM, Osuchowski MF, Wang JH, Pan ZK.   Editorial: Immune Dysfunction: An Update of New Immune Cell Subsets and Cytokines in Sepsis.     Front Immunol. 2021 Dec 16;12:822068. doi: 10.3389/fimmu.2021.822068. eCollection 2021.PMID: 34975929 

Chen X, Liu Y, Dolin H, Liu J, Jiang Y, Pan ZK.      Pinaverium Bromide Attenuates Lipopolysaccharide-Induced Excessive Systemic Inflammation via Inhibiting Neutrophil Priming.    J Immunol. 2021 Apr 15;206(8):1858-1865. doi: 10.4049/jimmunol.1900975. Epub 2021 Mar 26.  J Immunol. 2021. PMID: 33771933

Creeden JF, Imami AS, Eby HM, Gillman C, Becker KN, Reigle J, Andari E, Pan ZK, O'Donovan SM, McCullumsmith RE, McCullumsmith CB.   Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infection.    Biomed Pharmacother.  138:111437. doi: 10.1016/j.biopha.2021.111437. Epub 2021 Feb 25.

Lu X, Wang J, Chen X, Jiang Y, Pan ZK.   Rolipram Protects Mice from Gram-negative Bacterium Escherichia coli-induced Inflammation and Septic Shock.  Scientific Reporters; 10(1):175. doi: 10.1038/s41598-019-56899-6. 2020

 Dolin HH, Papadimos TJ, Chen X, and Pan ZK.   Characterization of pathogenic sepsis etiologies and patient profiles: a novel approach to triage and treatment. Microbiology Insights    12: 1-8. 2019. 

Liu Y, Ota T, Chen X, Dolin H, Pan K, Takashima A,  Hinohara A, Pan ZK.  Gene Expression Analysis on Neutrophil-Dendritic Hybrid Cells in Synovial Fluid from Rheumatoid Arthritis (RA) Patient.  J Clin Cell Immunol 10: 575. doi:10.4172/2155-9899.1000575. 2019. 

Liu W, Pan K, Chen X, Dolin H, Chen G, Pan ZK. Synergistic Induction of CCL20 and Dendritic Cell Migration by Bacterial Chemoattractant fMLP and TLR2 Agonist: Roles of ERK/MAP Kinase. Clinical Microbiology: Open Access. 7:5 doi:10.4172/2327-5073. 1000316. 2018.

Dolin HH, Papadimos TJ, Stepkowski S, Chen X, Pan ZK. A novel combination of biomarkers to herald the onset of sepsis prior to the manifestation of symptoms. Shock. 49(4):364-370. doi: 10.1097/SHK.0000000000001010. 2018.

Pan Y, Xu C, Pan ZK. MKP-1 negative regulates Staphylococcus aureus induced inflammatory responses in Raw264.7 cells: roles of PKA-MKP-1 pathway and enhanced by rolipram. Scientific Reporters; 7(1):12366. doi: 10.1038/s41598-017-10187-3. 2017.

 

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