Bina Joe, Ph.D., FAHA, FAPS, ISHF

Distinguished University Professor and Chair, Physiology and Pharmacology
Frederick-Hiss Endowed Professor
Founding Executive Director, Center for Hypertension and Precision Medicine
Principal Investigator, Program in Physiological Genomics
Phone: 419.383.4415
Email: Bina.Joe@utoledo.edu

complete list of publications

highlighted publications

Microbial reconstitution reverses early female puberty induced by maternal high-fat diet during lactation. Wang M, Zhang Y, Miller D, Rehman NO, Cheng X, Yeo JY, Joe B, Hill JW. Endocrinology. 2019 (In Press) PMID:31912132

Galla*, Saroj Chakraborty*, Xi Cheng, Ji-Youn Yeo, Blair Mell, Nathaline Chiu, Camilla F. Wenceslau, Matam Vijay-Kumar, Bina Joe. Exposure to amoxicillin in early life is associated with changes in gut microbiota and reduction in blood pressure: Findings from a study on rat dams and offspring. JAHA2019, In Press. (Article reference # JAHA/2019/014373R3) * First authors

Vertical selection for nuclear and mitochondrial genomes shapes gut microbiota and modifies risks for complex diseases. Zhang Y, Kumarasamy S, Mell B, Cheng X, Morgan EE, Britton SL, Vijay-Kumar M, Koch LG, Joe B. Physiol Genomics. 2019 Nov 25. doi: 10.1152/physiolgenomics.00089.2019. [Epub ahead of print] PMID: 31762410

Edwards JM*, Roy* S, Tomcho JC, Schreckenberger ZJ, Chakraborty S, Bearss NR, Saha P, McCarthy CG, Vijay-Kumar M, Joe B, Wenceslau CF. Microbiota are critical for vascular physiology: Germ-free status weakens contractility and induces sex-specific vascular remodeling in mice. Vascular Pharmacology. In Press (Article reference #VPH_106633). *First authors.

Sarah Galla*, Saroj Chakraborty*, Xi Cheng, Ji-Youn Yeo, Blair Mell, Nathaline Chiu, Camilla F. Wenceslau, Matam Vijay-Kumar, Bina Joe. Exposure to amoxicillin in early life is associated with changes in gut microbiota and reduction in blood pressure: Findings from a study on rat dams and offspring. JAHA2019, In Press. (Article reference # JAHA/2019/014373R3)
* First authors

cell reports

Chakraborty S, Galla S, Cheng X, Yeo JY, Mell B, Singh V, Yeoh B, Saha P, Mathew AV, Vijay-Kumar M, Joe B. Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension. Cell reports. 2018 PMCID:PMC6232850 (click title to view article)

*Singh V, Yeoh BS, Chassaing B, Xiao X, Saha P, Aguilera Olvera R, Lapek JD Jr, Zhang L, Wang WB, Hao S, Flythe MD, Gonzalez DJ, Cani PD, Conejo-Garcia JR, Xiong N, Kennett MJ, Joe B, Patterson AD, Gewirtz AT, Vijay-Kumar M.Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer. Cell 2018 PMID:30340040 PMCID:PMC6232850 (click title to view article) *Article highlighted by commentary published in Cell Metabolism: https://www.cell.com/cell-metabolism/pdf/S1550-4131(18)30641-7.pdf

Waghulde, H., Cheng, X., Galla, S., Mell, B., Cai, J., Pruett-Miller, S.M., Vazquez, G., Patterson, A.D., Vijay-Kumar, M., and Joe, B. (2018) Attenuation of microbiotal dysbiosis and hypertension in a CRISPR/CAS9 gene ablation rat model of Gper1. Hypertension. PMID:30095376 PMCID:PMC6230872

Sherman SB, Sarsour N, Salehi M, Schroering A, Mell B, Joe B, Hill JW. Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis. Gut microbes. 2018; PMID:29469650 PMCID: PMC6219642

Mell B, Jala VR, Mathew AV, Byun J, Waghulde H, Zhang, Y, Haribabu B, Vijay-kumar M, Pennathur S, Joe B. Evidence for a link between Gut Microbiota and Hypertension in the Dahl rat model.Physiol Genomics 2015, 47(6):187-197. PMID: 25829393

Singh V, Yeoh BS, Kumar M, Bachman M, Borregaard N, Joe B, Vijay-Kumar M. Interplay between enterobactin, myeloperoxidase and lipocalin 2 regulates E. coli survival in the inflamed gut.Nature Communications. 2015. 6:7113, PMID: 25964185

Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase (SCD1) Determines Metabolic Syndrome in TLR5-Deficient Mice. Singh V, Chassaing B, , Zhang L, Yeoh BS, Xiao X, Kumar M, Baker MT, Wei J, Walker R, Harvatine K, Singh N, Shearer GC, Ntambi JM, Joe B, Patterson AD, Gewirtz AT, Vijay-Kumar M. Cell Metabolism, 2015 22: 983-986. PMID: 26525535

Yeoh BS, Overa, RA, Singh V, Xiao X, Saha P, Joe B, Lambert JD, Vijay-Kumar M. (2016) Epigallocatechin- 3-gallate inhibition of myeloperoxidase and its counter-regulation by dietary iron and lipocalin 2 in murine model of gut inflammation. Am J Pathol 2016, 186:912-926

Xi Cheng, Harshal Waghulde, Blair Mell, Eric E. Morgan, Shondra M. Pruett-Miller, Bina Joe. Positional cloning of quantitative trait nucleotides for blood pressure and cardiac QT-interval by targeted CRISPR/Cas9 editing of a novel long non-coding RNA. 2017; PLOS Genetics. 13:e1006961, PMID: 28827789

*Padmanabhan S, Joe B. Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans. 2017; Physiological Reviews 97(4):1469-1528, PMID: 28931564. *Cover article

*#Xi Cheng, Bina Joe. Circular RNAs in rat models of cardiovascular and renal diseases. 2017; Physiological Genomics. PMID: 28778982. * Article selected for American Physiological Society (APS) Select, # Article was associated with a press release from the APS http://www.the-aps.org/mm/hp/Audiences/Public- Press/2017/64.html

Atanur SS, Diaz AG, Maratou K, Sarkis A, Rotival M, Game L, Tschannen MR, Kaisaki PJ, Otto GW, Ma MCJ, Keane TM, Hummel O, Saar K, Chen W, Guryev V, Gopalakrishnan K, Garrett MR, Joe B, Citterio L, Bianchi G, McBride M, Dominiczak A, Adams DJ, Serikawa T, Flicek P, Cuppen E, Hubner N, Petretto E, Gauguier D, Kwitek A, Jacob H, and Aitman TJ. Genome Sequencing Reveals Loci under Artificial Selection that Underlie Disease Phenotypes in the Laboratory Rat. Cell 2013, 154: 691-703, PMID:2389082

Kumarasamy S, Waghulde H, Gopalakrishnan K, Mell B, Morgan E, Joe B. Cross-talk between two transcription factors, Nr2f2 and Fog2, is critical for maintenance of normal blood pressure.Nature Communications 2015 6: 6252, 2015, PMID 25687237

Furuya, T, B. Joe, J. L. Salstrom, A. Hashiramoto, D. E. Dobbins, R. L. Wilder, E. F. Remmers. Polymorphisms of the tumor necrosis factor alpha locus among autoimmune disease susceptible and resistant inbred rat strains. Genes and Immunity 2: 229-232, 2001. PMID: 11477479

Remmers, E. F., B. Joe, M. M. Griffiths, D. E. Dobbins, S. Dracheva, A. Hashiramoto, T. Furuya, J. L. Salstrom, J. Wang, P. S. Gulko, G. W. Cannon, R. L. Wilder. Modulation of multiple experimental arthritis models by collagen-induced arthritis quantitative trait loci isolated in congenic rat lines: different effects of non-major histocompatibility complex quantitative trait loci in males and females. Arthritis Rheum 46:2225- 2234, 2002. PMID: 12209529

Potenza, MN, E.S. Brodkin, B. Joe, X. Luo, E.F. Remmers, R.L. Winder, E.J. Nestler, J. Gelernter. Genomic regions controlling corticosterone level in rats. Biol. Psychiatry 55: 634-641, 2004. PMID: 15013833

Brenner M, H. Meng, C. Nuriza, B.S. Yarlett, B. Joe, M. M. Griffiths, E. F. Remmers, R. L. Wilder, P. Gulko. The non-MHC quantitative trait locus Cia5 contains two major arthritis genes that differentially regulate disease severity, pannus formation and joint damage in collagen-and pristane- induced arthritis. J. Immunol. 174: 7894-7903, 2005. PMID: 15944295

research interests

The Program in Physiological Genomics of the Department of Physiology and Pharmacology is focused on understanding the genetic components of pathophysiological conditions of the cardiovascular, renal and autoimmune systems. The most prominent of all complex traits investigated in the Joe laboratory is blood pressure regulation. Rat models serve as valuable alternatives to human studies for the identification and characterization of genetic factors/genes. The main strategy is to identify the disease causative genetic factor/gene based on its location on the rat genome by linkage analysis and substitution mapping and/or gene expression and protein expression profiling using whole genome systems biology approaches. We have identified at least 16 different genomic regions that harbor quantitative trait loci (QTLs) for hypertension in rats and successfully mapped several of these regions to unparalleled resolutions of a few kilobases. Positional cloning projects have progressed to the identification of multiple novel genes as prominent BP QTLs in rats. Methodical mechanistic studies spanning from molecular to whole-organism physiology/pathophysiology are underway to determine the functional significance of the novel BP QTLs identified. Genetic-engineering technologies such as the application of zinc-finger nuclease-based targeted gene disruption for creation of 'knock-out' and 'knock-in' rat models are also strategies integrated into our research for validation of the positionally cloned causal genetic biomarkers of blood pressure regulation. Finally, the translational significance of our work is exemplified by the validation of the positionally cloned rat genes as being associated or linked with human hypertension.

Appointments

Frederick-Hiss Endowed Professor, Distinguished University Professor and Chair 2020-present
Distinguished University Professor and Chair 2017-present
Chair, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Health Science Campus, 2015-present
Professor, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Health Science Campus, 2011-2017
Associate Professor (Awarded Tenure 2008), Department of Physiology and Pharmacology, University of Toledo College of Medicine, Health Science Campus, July 2007-2010
Assistant Professor, Department of Physiology, Pharmacology, Metabolism, and Cardiovascular Sciences, University of Toledo College of Medicine, Health Science Campus, April 2004-June 2007
Scientific Advisor, Rat Genome Database (http://rgd.mcw.edu/), 2003-present
Research Assistant Professor, Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, OH, Apr 2001- Mar 2004
Scientist, ASTRA, Bangalore, India, 1996-1997

honors and awards

2022 Ernest Starling Distinguished Lectureship, Water and Electrolyte Section, American Physiological Society, USA
2022 Arthur C. Guyton Distinguished Lectureship Award, Association of Chairs of Departments of Physiology (ACDP)
2022 Outstanding Advisor Award, University of Toledo
2020 2020 Mayerson-DiLuzio Lectureship, Tulane University School of Medicine, New Orleans, LA
2020 Fellow of the International Society of Hypertension (ISHF)
2019 Harriet Dustan Award, American Heart Association, Council on Hypertension, New Orleans, LA
2019 Distinguished Lecturership Award, Physiological Omics Group, American Physiological Society
2019 President’s Award for Excellence in Grantsmanship, University of Toledo
2018 APSselect Award for Distinction in Scholarship, American Physiological Society, Physiological Genomics Group
2018 President’s Award for Outstanding Scholar, University of Toledo
2017 Distinguished University Professor, University of Toledo
2017 President’s Award for Excellence in Grantsmanship, University of Toledo
2015 Outstanding Researcher Award, University of Toledo
2015 Research Shining Star Award-Provost Office, University of Toledo
2014 Lewis Dahl memorial Lecturer, Council for Hypertension, American Heart Association
2014 Distinguished Service Award, American Physiological Society, Physiological Genomics Group
2011 Appointed by the Chancellor at UT-Change Leader for Institutions developing excellence in academic leadership
2011 Annual Presidential Address: Highlighted as one of 9 Outstanding Young Faculty at the University of Toledo
2010 Fellow of the American Heart Association (FAHA)
2010 American Society of Hypertension Young Scholar Award
1997 Fogarty International visiting scientist fellowship award, NIH, Bethesda, USA
1993 Nationally competitive Senior Research Scholarship award, Council for Scientific and Industrial Research, India
1990 Nationally competitive Junior Research Scholarship award, Council for Scientific and Industrial Research, India
1988-90 National Merit Scholarship award, India